John S Lazo Selected Research

SARS-CoV-2 spike protein

1/2021

The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells.

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John S Lazo Research Topics

Disease

52	Neoplasms (Cancer) 01/2023 - 01/2003
6	Prostatic Neoplasms (Prostate Cancer) 01/2016 - 01/2004
5	Ovarian Neoplasms (Ovarian Cancer) 04/2024 - 02/2018
5	Carcinogenesis 01/2013 - 04/2002
5	Glioblastoma (Glioblastoma Multiforme) 12/2012 - 10/2009
4	Alzheimer Disease (Alzheimer's Disease) 01/2018 - 01/2005
3	Breast Neoplasms (Breast Cancer) 12/2019 - 06/2011
3	Lung Neoplasms (Lung Cancer) 08/2010 - 02/2003
2	Hematologic Neoplasms (Hematological Malignancy) 12/2020 - 01/2018
2	Neoplasm Metastasis (Metastasis) 12/2020 - 01/2013
2	Squamous Cell Carcinoma of Head and Neck 09/2015 - 01/2014
2	Leishmaniasis 03/2014 - 11/2009
2	Cutaneous Leishmaniasis 03/2014 - 11/2009
2	Acquired Immunodeficiency Syndrome (AIDS) 01/2013 - 11/2009
2	Colonic Neoplasms (Colon Cancer) 01/2013 - 10/2009
2	Glioma (Gliomas) 01/2010 - 12/2009
2	Hepatocellular Carcinoma (Hepatoma) 02/2003 - 05/2002
1	COVID-19 01/2023
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2023
1	Lung Injury 01/2021
1	Body Weight (Weight, Body) 01/2021
1	Acute Lung Injury 01/2021
1	Frontotemporal Dementia (Semantic Dementia) 01/2020
1	Colorectal Neoplasms (Colorectal Cancer) 10/2018
1	Type 2 Diabetes Mellitus (MODY) 01/2018
1	Amyloid Plaque 01/2018
1	Pathologic Processes 05/2014
1	Pathologic Neovascularization 02/2014
1	Seasonal Allergic Rhinitis (Hay Fever) 01/2014
1	Vasomotor Rhinitis 01/2014
1	Conjunctivitis 01/2014

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2003
13	Phosphoric Monoester Hydrolases (Phosphatases)IBA 04/2024 - 01/2007
13	Protein Tyrosine PhosphatasesIBA 04/2024 - 02/2003
8	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 12/2019 - 01/2003
7	JMS-053IBA 01/2023 - 02/2018
7	Small Interfering RNA (siRNA)IBA 12/2012 - 12/2009
6	Dual-Specificity PhosphatasesIBA 01/2023 - 04/2002
5	Tyrosine (L-Tyrosine)FDA Link 05/2014 - 02/2003
4	Phosphotransferases (Kinase)IBA 01/2023 - 01/2004
4	Oncogene Proteins (Oncogene Protein)IBA 02/2018 - 09/2003
4	DNA (Deoxyribonucleic Acid)IBA 08/2010 - 05/2005
3	CytokinesIBA 04/2024 - 01/2014
3	Messenger RNA (mRNA)IBA 01/2013 - 02/2003
3	Paclitaxel (Taxol)FDA LinkGeneric 06/2011 - 02/2008
3	cdc25 PhosphatasesIBA 10/2009 - 01/2004
3	Mitogen-Activated Protein KinasesIBA 08/2006 - 01/2004
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2021 - 01/2014
2	Antineoplastic Agents (Antineoplastics)IBA 01/2021 - 10/2005
2	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 12/2019 - 01/2018
2	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2019 - 09/2005
2	Drug CombinationsIBA 01/2018 - 12/2011
2	AndrogensIBA 01/2016 - 01/2004
2	Interleukin-6 (Interleukin 6)IBA 09/2015 - 01/2014
2	CarcinogensIBA 01/2013 - 02/2003
2	LigandsIBA 10/2012 - 02/2005
2	Vinblastine (Vinblastine Sulfate)FDA Link 12/2011 - 02/2010
2	furanIBA 01/2011 - 06/2009
2	Phorbol EstersIBA 01/2011 - 11/2008
2	protein kinase DIBA 12/2010 - 05/2010
2	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2009 - 03/2007
2	EnzymesIBA 03/2009 - 04/2002
2	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideIBA 10/2007 - 02/2003
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 09/2007 - 09/2006
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 03/2007 - 01/2004
2	2,3- bis(2- hydroxyethylsulfanyl)- (1,4)naphthoquinoneIBA 01/2004 - 04/2002
1	Teniposide (VM 26)FDA Link 01/2023
1	pyridineIBA 01/2023
1	SARS-CoV-2 spike proteinIBA 01/2021
1	Human Serum Albumin FDA LinkGeneric 12/2020
1	Serum AlbuminIBA 12/2020
1	elastin microfibril interface located protein (emilin)IBA 10/2018
1	Amyloid (Amyloid Fibrils)IBA 01/2018
1	Insulin (Novolin)FDA Link 01/2018
1	abirateroneIBA 01/2016
1	Prostate-Specific Antigen (Semenogelase)IBA 01/2016
1	enzalutamideIBA 01/2016
1	Androgen Receptors (Androgen Receptor)IBA 01/2016
1	TriterpenesIBA 10/2015
1	celastrolIBA 10/2015
1	Transcription Factor 3IBA 09/2015
1	GoldIBA 03/2014
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2014
1	Transcription Factors (Transcription Factor)IBA 01/2014
1	ColforsinIBA 01/2014
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2014
1	Histamine H1 Receptors (Histamine H1 Receptor)IBA 01/2014
1	Adenosine Monophosphate (AMP)IBA 01/2014
1	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 01/2014
1	azelastine (Optivar)FDA LinkGeneric 01/2014
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2013
1	Dextrans (Dextran)FDA Link 01/2013
1	AzoxymethaneIBA 01/2013
1	Temozolomide (Temodar)FDA LinkGeneric 12/2012
1	Alkylating AgentsIBA 12/2012

Therapy/Procedure

14	Therapeutics 01/2023 - 12/2007
3	Drug Therapy (Chemotherapy) 12/2012 - 10/2009
2	Radiotherapy 01/2011 - 10/2009
1	TP protocol 01/2023
1	Castration 01/2016